Tau and Post-Injury Epilepsy, Neurodegeneration and Neuropsychiatric

Grant number: 1006077 | Funding period: 2011 - 2013

Completed

Abstract

This project will explore a new approach to the prevention and treatment of epilepsy and the associated mental health disorders following a brain injury. This involves inhibiting pathological forms of the Tau protein, which has been implicated in the development of epilepsy and neurodegeneration. The drug that will be tested in this study has already been demonstrated to be safe and well tolerated in humans, meaning that a positive result from these studies could be expediently translated into clinical studies.

Related publications (8)

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Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

BD Semple, A Zamani, G Rayner, SR Shultz, NC Jones

2019-03-01

Survivors of traumatic brain injury (TBI) often develop chronic neurological, neurocognitive, psychological, and psychosocial defi..

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Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice

S Liu, Y Shen, SR Shultz, A Nguyen, C Hovens, PA Adlard, AI Bush, J Chan, P Kwan, TJ O'Brien, NC Jones

2017-09-01

The biologic processes underlying epileptogenesis following a brain insult are not fully understood, but several lines of evidence..

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Traumatic brain injury results in cellular, structural and functional changes resembling motor neuron disease

DK Wright, S Liu, C Van Der Poel, SJ McDonald, RD Brady, L Taylor, L Yang, AJ Gardner, R Ordidge, TJ O'Brien, LA Johnston, SR Shultz

2017-01-01

Traumatic brain injury (TBI) has been suggested to increase the risk of amyotrophic lateral sclerosis (ALS). However, this link re..

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Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau

SJ Liu, P Zheng, DK Wright, G Dezsi, E Braine, T Nguyen, NM Corcoran, LA Johnston, CM Hovens, JN Mayo, M Hudson, SR Shultz, NC Jones, TJ O'Brien

2016-07-01

There are no treatments in clinical practice known to mitigate the neurobiological processes that convert a healthy brain into an ..

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Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

SR Shultz, DK Wright, P Zheng, R Stuchbery, SJ Liu, M Sashindranath, RL Medcalf, LA Johnston, CM Hovens, NC Jones, TJ O'Brien

2015-05-01

Traumatic brain injury is a common and serious neurodegenerative condition that lacks a pharmaceutical intervention to improve lon..

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Granulocyte-macrophage colony-stimulating factor is neuroprotective in experimental traumatic brain injury

SR Shultz, XL Tan, DK Wright, SJ Liu, BD Semple, L Johnston, NC Jones, AD Cook, JA Hamilton, TJ O'Brien

2014-05-15

Traumatic brain injury (TBI) is an international health concern with a complex pathogenesis resulting in major long-term neurologi..

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DNA Methylation Mediates Persistent Epileptiform Activity In Vitro and In Vivo

ZM Machnes, TCT Huang, PKY Chang, R Gill, N Reist, G Dezsi, E Ozturk, F Charron, TJ O'Brien, NC Jones, RA McKinney, M Szyf

2013-10-02

Epilepsy is a chronic brain disorder involving recurring seizures often precipitated by an earlier neuronal insult. The mechanisms..

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Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models

NC Jones, T Nguyen, NM Corcoran, D Velakoulis, T Chen, R Grundy, TJ O'Brien, CM Hovens

2012-03-01

Tau hyperphosphorylation has been implicated in the pathogenesis of a variety of forms of human epilepsy. Here we investigated whe..